Comedian Matt Iseman Live in Naples, Florida!

Emmy Award–winning host, comedian, and self-proclaimed “professional talker,” Matt Iseman has made a career out of making people laugh while somehow sneaking in a little inspiration along the way. Best known as the energetic host of American Ninja Warrior and a fan favorite winner of The New Celebrity Apprentice with Arnold Schwarzenegger, Matt brings the same charm, quick wit, and larger-than-life personality to the stand-up stage that have made him a household name.

Before comedy, Matt graduated from Princeton University and earned his M.D. from Columbia University—only to realize that telling jokes was a lot more fun than writing prescriptions. Trading the hospital for Hollywood, he’s since appeared on shows ranging from Clean House to The Today ShowThe Kelly Clarkson Show, and quite possibly the most memorable turn with his win on Lip Sync Battle, proving his comedic versatility across TV and live audiences alike.

Known for his clean, relatable humor and infectious positivity, Matt draws from his unique journey—from doctor to entertainer, cancer survivor to TV personality—to deliver a show that’s as uplifting as it is hilarious. Whether he’s sharing behind-the-scenes tales from the Ninja Warrior course or poking fun at his own life choices, Matt’s comedy is a reminder that laughter really is the best medicine… even when prescribed by a guy who quit being a doctor.

03/15/2026 6:00 PM
Other Showtimes

PLEASE NOTE THAT WE CAN’T GUARANTEE EVERYONE IN YOUR PARTY WILL BE SEATED TOGETHER UNLESS ALL TICKETS WERE PURCHASED UNDER ONE ORDER.

IF YOUR PARTY ORDERED TICKETS SEPARATELY, PLEASE CONTACT OUR BOX OFFICE TO LET US KNOW THAT YOU'LL BE PART OF A GROUP AND WE WILL DO OUR BEST TO SEAT YOU TOGETHER.


FOR ALL FIRST SCHEDULED SHOWTIMES OF THE EVENING - DOORS OPEN TWO HOURS PRIOR TO SHOWTIME.

  • (Ex. 7PM = doors open at 5PM.)

SECOND/THIRD SCHEDULED SHOWTIMES - DOORS OPEN 15 MINUTES PRIOR TO SHOWTIME. WE RECOMMEND ARRIVING 30-45 MINUTES PRIOR TO DOORS OPENING. CHECK IN IS OUTSIDE FOR THESE SHOWS.

All admissions are host escorted to your seat - you do not make any table reservations or table requests.

VIP Admission is preferred seating within the 5-7 rows in front of the stage. 2 item minimum purchase per person is required.

General Admission is selected by the club at time of arrival. 2 item minimum purchase per person is required.

VIP Suite of 5 is located on the side wall on a raised platform. This is private table for up to 5 guests Maximum.

    Each show has a 2 item minimum purchase per person. (any combination of food & beverage will satisfy our minimums.)

    IF YOU HAVE PURCHASED A VIP SUITE OF 5 - A $200.00 MINIMUM AT THE TABLE IS REQUIRED AMONGST YOUR PARTY.

    18% Gratuity added to all checks - ANY ADD ON’s PRE-PURCHASED ONLINE WILL ALSO ADD 18% GRATUITY.


  • Valid Photo ID Is Required To Pick Up Your Tickets | You Can Also Print Out Your Tickets Or Pull Them Up On Your Smartphone!
  • Management Reserves The Right To Release Your Tickets/Seats If You Do Not Arrive By Scheduled Showtime

WE HAVE THE RIGHT TO COLLECT, USE & STORE PERSONAL INFORMATION LIKE CELLPHONE NUMBERS & EMAIL ADDRESSES WHEN USING OUR SERVICES. ALL PERSONAL INFORMATION IS STRICTLY PROTECTED IN OUR DATABASE AND FURTHER ASSISTS US WITH PROVIDING THE UPMOST EXPERIENCE FOR OUR GUESTS.

ALL SALES ARE FINAL AND NO REFUNDS WILL BE GIVEN UNDER ANY CIRCUMSTANCES - UNLESS TICKET INSURANCE IS PURCHASED AND REDEEMED FOUR HOURS PRIOR TO SCHEDULED SHOW.

PLEASE DON'T PURCHASE TICKETS FROM ANY OTHER SITE. TICKET RESALE IS STRICTLY PROHIBITED. YOUR NAME, CREDIT CARD, ADDRESS, AND EMAIL ADDRESS WILL BE VERIFIED. TICKETS SUSPECTED OF BEING PURCHASED FOR THE SOLE PURPOSE OF RESELLING WILL BE CANCELLED AT THE DISCRETION OF OFF THE HOOK COMEDY CLUB.

PLEASE NOTE SEATING IS FIRST COME FIRST SERVE BASIS WHETHER VIP OR GENERAL ADMISSION.

SPECIAL OCCASION? Groups Of 20+ Are Eligible For Exclusive Food & Beverage Packages That Also Include Guaranteed Reserved Seating! For more information, email boxoffice@offthehookcomedy.com


DO NOT PURCHASE TICKETS FROM ANYONE OR ANY OTHER SITE OTHER THAN OFFTHEHOOKCOMEDY.COM OR OUR OFFICIAL EVENTBRITE SITE.

Emmy Award–winning host, comedian, and self-proclaimed “professional talker,” Matt Iseman has made a career out of making people laugh while somehow sneaking in a little inspiration along the way. Best known as the energetic host of American Ninja Warrior and a fan favorite winner of The New Celebrity Apprentice with Arnold Schwarzenegger, Matt brings the same charm, quick wit, and larger-than-life personality to the stand-up stage that have made him a household name.

Before comedy, Matt graduated from Princeton University and earned his M.D. from Columbia University—only to realize that telling jokes was a lot more fun than writing prescriptions. Trading the hospital for Hollywood, he’s since appeared on shows ranging from Clean House to The Today ShowThe Kelly Clarkson Show, and quite possibly the most memorable turn with his win on Lip Sync Battle, proving his comedic versatility across TV and live audiences alike.

Known for his clean, relatable humor and infectious positivity, Matt draws from his unique journey—from doctor to entertainer, cancer survivor to TV personality—to deliver a show that’s as uplifting as it is hilarious. Whether he’s sharing behind-the-scenes tales from the Ninja Warrior course or poking fun at his own life choices, Matt’s comedy is a reminder that laughter really is the best medicine… even when prescribed by a guy who quit being a doctor.